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Figure 1 | Reproductive Biology and Endocrinology

Figure 1

From: The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle

Figure 1

In situ hybridization of BMP-2 mRNA in the ovaries of adult cycling rats. Brightfield (A, D, F, H, J, L, N) and Darkfield (B, C, E, G, I, K, M). A, B: Sections from a DII 1100 h ovary (4X); new corpus luteum (CL-I); atretic follicle (AF); secondary interstitial cells (SIC); healthy Graafian follicle (GF); C: Negative control hybridized with sense BMP-2 cRNA probe; D, E: Secondary follicle with 3–5 layers of GCs at DII 1100 h (20X). Note positive membrana GC at periphery. F, G: Dominant follicle at DII 1100 h (10X); Positive membrana GC (MGC); Negative oocyte (O), cumulus GC (CC), periantral GC (PA) and theca (T); H, I: Atretic follicle at P 1000 h showing strongly positive GC (10X); J, K: Negative newly formed CL-I at E 0200 h (4X); Positive GF and preantral follicle (arrow); L, M: New CL-I after initiation of luteolysis at DII 1100 h showing clusters of positive cells (20X); N: Higher magnification (40X) of CL-I in L showing positive endothelial and granulosa lutein cells (GLC).

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