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Table 1 Transposable elements active in vertebrate species for use as gene transfer and insertional mutagenesis vectors.

From: Generating and manipulating transgenic animals using transposable elements

Transposon Familya Activity in cultured cellsb Activity in vertebrate animalsc References
L1 LINE retrotransposon Mouse (PCT) Human (PCT) Mouse (TCRG) [21, 22]
Tol2 hAT Mouse (EP) Human (EP) Medaka (TCRG) Zebrafish (TCRG). [27, 28, 32]
Tc1 Tc1/mariner Human (PCT) Mouse (PCT) - [19, 39, 40]
Tc3 Tc1/mariner Human (PCT) Zebrafish (GT and TCRG) [19, 42]
Mariner (Himar1) Tc1/mariner Human (IPT) - [19, 44]
Mariner (Mos1) Tc1/mariner Human (PCT) Chicken (GT), zebrafish (GT) [5, 19, 43]
Minos Tc1/mariner Human (PCT) Mouse (TCRG) Mouse (TCRS) [4648]
Sleeping Beauty Tc1/mariner Mouse, hamster, human, monkey, dog, cow, sheep, quail, Xenopus, many fish (PCT) Mouse (GT) Mouse lung, liver (SCT) Mouse (TCRG) Mouse (TCRS) [4, 19, 30, 51, 5356, 59, 60]
  1. aRelevant superfamily of transposable element. bActivity in immortalized cell lines has been demonstrated using by demonstrating excision from an introduced plasmid (EP), interplasmid transposition (IPT), or full transposition from introduced plasmid (or viral vector) into chromosomes (PCT). cActivity in intact animals (various species) has been demonstrated by germline transgenesis (GT), somatic cell transgenesis (SCT), transposition of chromosomally resident transposon vectors in the germline (TCRG), and transposition of chromosomally resident transposon vectors in the soma (TCRS).