Skip to main content

Table 1 Transposable elements active in vertebrate species for use as gene transfer and insertional mutagenesis vectors.

From: Generating and manipulating transgenic animals using transposable elements

Transposon

Familya

Activity in cultured cellsb

Activity in vertebrate animalsc

References

L1

LINE retrotransposon

Mouse (PCT) Human (PCT)

Mouse (TCRG)

[21, 22]

Tol2

hAT

Mouse (EP) Human (EP)

Medaka (TCRG) Zebrafish (TCRG).

[27, 28, 32]

Tc1

Tc1/mariner

Human (PCT) Mouse (PCT)

-

[19, 39, 40]

Tc3

Tc1/mariner

Human (PCT)

Zebrafish (GT and TCRG)

[19, 42]

Mariner (Himar1)

Tc1/mariner

Human (IPT)

-

[19, 44]

Mariner (Mos1)

Tc1/mariner

Human (PCT)

Chicken (GT), zebrafish (GT)

[5, 19, 43]

Minos

Tc1/mariner

Human (PCT)

Mouse (TCRG) Mouse (TCRS)

[46–48]

Sleeping Beauty

Tc1/mariner

Mouse, hamster, human, monkey, dog, cow, sheep, quail, Xenopus, many fish (PCT)

Mouse (GT) Mouse lung, liver (SCT) Mouse (TCRG) Mouse (TCRS)

[4, 19, 30, 51, 53–56, 59, 60]

  1. aRelevant superfamily of transposable element. bActivity in immortalized cell lines has been demonstrated using by demonstrating excision from an introduced plasmid (EP), interplasmid transposition (IPT), or full transposition from introduced plasmid (or viral vector) into chromosomes (PCT). cActivity in intact animals (various species) has been demonstrated by germline transgenesis (GT), somatic cell transgenesis (SCT), transposition of chromosomally resident transposon vectors in the germline (TCRG), and transposition of chromosomally resident transposon vectors in the soma (TCRS).