Figure 1

Effects of ICI 182, 780 in the expression of ERα, ERβ and AR in the rat testis. (A) Leydig cells (L) and some myoid cells (arrow) are positive for ERα in the control rats. (B) ERα immunostaining is not detected after 100 days of ICI treatment. (C) ERβ was strongly expressed in the Sertoli cells (S) and slightly expressed in the germ cells in the seminiferous epithelium (E) and interstitial cells (L). (D) The ERβ expression was unaffected by the ICI treatment, as shown at day 45. (E) AR expression was found in the Sertoli cells (S), Leydig cells (L) and peritubular myoid cells (arrow). (F) There were no detectable effects on the AR expression after ICI treatment, as shown at day 45. Bar in A = 50 μm.