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Table 2 Phenotypic differences of NFH-OSE and FH-OSE in culture

From: Ovarian surface epithelium: family history and early events in ovarian cancer

  NFH-OSE FH-OSE
Response to environmental signals greater lesser
Growth potential greater lesser
Telomeric length longer shorter
Metaplastic colonies in primary culture rare frequent
Expression of   
   CA125 rare prominent
   E-cadherin rare prominent
   High molecular weight keratin less more
   Collagen III more less
Coexpression of HGF and Met receptor rare frequent
Signaling pathways (such as PI3K) non-activated activated