Ovarian surface epithelium: family history and early events in ovarian cancer

Table 2 Phenotypic differences of NFH-OSE and FH-OSE in culture

	NFH-OSE	FH-OSE
Response to environmental signals	greater	lesser
Growth potential	greater	lesser
Telomeric length	longer	shorter
Metaplastic colonies in primary culture	rare	frequent
Expression of
CA125	rare	prominent
E-cadherin	rare	prominent
High molecular weight keratin	less	more
Collagen III	more	less
Coexpression of HGF and Met receptor	rare	frequent
Signaling pathways (such as PI3K)	non-activated	activated

ISSN: 1477-7827