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Table 1 Histopathologic alterations of ovaries from women with family history of ovarian cancer

From: Ovarian surface epithelium: family history and early events in ovarian cancer

 

Present

Absent

Histologic

  

Metaplasia of surface epithelium

[13]

[14–17]

   Papillomatosis

  

   Stratification

  

   Epithelial inclusion cysts

  

   Invaginations

  

Stromal hyperplasia

[13]

[14, 15]

Cytologic

  

Nuclei of the surface epithelium

[14, 16, 18]

 

   Larger nuclei

  

Irregular contours

  

Heterogenous dense chromatin

  

Molecular

  

Increased expression of p53, c-erbB and Ki-67

 

[15, 19]