The antiestrogen ICI 182,780 induces early effects on the adult male mouse reproductive tract and long-term decreased fertility without testicular atrophy

Table 2 Reproductive performance in mice after antiestrogen treatment^a.

Parameter	Control	ICI-Treated
Percent Progressive Sperm Motility	34.5 ± 2.90%	7.2 ± 3.11%^b,c
Fertile males	6/6	2/6^d
Average litter size	8.0 ± 0.8	5.80 ± 1.3^e
Percentage of Resorptions/fetal deaths	12.3 ± 1.1%	20.67 ± 1.7%^c

^a N = 6 per group; mice were 118 days of age for fertility trials; 155 days of age at sacrifice. ^b Values are mean ± SEM ^c p < 0.05 by the chi-square test. ^d 4 of 6 males were infertile; subfertility was indicated by an increase in resorption in the 2 males that were fertile. ^e Not significantly different; p = 0.21 by t-test.

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