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Table 2 Reproductive performance in mice after antiestrogen treatmenta.

From: The antiestrogen ICI 182,780 induces early effects on the adult male mouse reproductive tract and long-term decreased fertility without testicular atrophy

Parameter Control ICI-Treated
Percent Progressive Sperm Motility 34.5 ± 2.90% 7.2 ± 3.11%b,c
Fertile males 6/6 2/6d
Average litter size 8.0 ± 0.8 5.80 ± 1.3e
Percentage of Resorptions/fetal deaths 12.3 ± 1.1% 20.67 ± 1.7%c
  1. a N = 6 per group; mice were 118 days of age for fertility trials; 155 days of age at sacrifice. b Values are mean ± SEM c p < 0.05 by the chi-square test. d 4 of 6 males were infertile; subfertility was indicated by an increase in resorption in the 2 males that were fertile. e Not significantly different; p = 0.21 by t-test.