Proximal region of efferent ductules from control (A, C) and ICI-treated (B, D) groups on day 4 post treatment. A. Control efferent ductules have a narrow diameter (double arrows). B. ICI treated ductules are dilated (double arrows) extensively by day 4. C-D. Higher magnification shows no change in the epithelium on day 4 post treatment. Bar = 50 μm for A, B. Bar = 25 μm for C, D.