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Figure 14 | Reproductive Biology and Endocrinology

Figure 14

From: The antiestrogen ICI 182,780 induces early effects on the adult male mouse reproductive tract and long-term decreased fertility without testicular atrophy

Figure 14

Corpus and cauda regions of the epididymis from control (A,C) and ICI-treated (B,D) males on day 8. A. Corpus epididymis in control. PAS-positive granules (arrow) are distributed in the perinuclear region of a clear cell (CC) that also contains a few apical vacuoles. Sperm (Sp) appear normal in the lumen. B. Corpus epididymis in ICI-treated. The clear cell appears to contain an increased number of apical vesicles and basal granules (arrow). Sperm appear normal in the lumen on day 8. C. Cauda epididymis in control. PAS-positive granules (arrow) are abundant in the perinuclear region of a clear cell. The principal cells (PC) have small vacuoles in the cytoplasm. Sperm (Sp) appear normal in the lumen. D. Cauda epididymis in ICI-treated. PAS-positive granules (large arrow) are more abundant in the basal region of a clear cell. There is an increase in the number of cytoplasmic vacuoles in the principal cells (small arrows). Sperm (Sp) appear normal in the cauda lumen on day 8. Bars = 25 μm for A, B. Bars = 12.5 μm for C, D.

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