Caput epididymis on day 125 post treatment. A. Control caput showing the apical cell (Ac) with and without apical PAS-positive granules. B. ICI-treated caput region showing increased number of the apical cells (arrows) that are engorged with PAS-positive granules. C. Higher magnification of ICI-treated caput region showing an increased size of the PAS-positive granules (large arrows) and the appearance of granules below the nucleus (small double arrows). Bars = 25 μm for A and C. Bar = 100 μm for B.