Dynamics of testicular germ cell apoptosis in normal mice and transgenic mice overexpressing rat androgen-binding protein

Table 2 Number (×10⁶) of germ cells undergoing apoptosis in age-matched control (WT) and in transgenic (TG) mice homozygous to rat ABP.

	Spermatogonia and Secondary spermatocytes (2C)		Spermatogonia synthesizing DNA (S-Phase)		Primary spermatocytes (4C)		Spermatids (1C)
Days	WT	TG	WT	TG	WT	TG	WT	TG
7 days	0.18 ± 0.04	0.23 ± 0.09	0.065 ± 0.026	0.065 ± 0.046	0.23 ± 0.061	0.26 ± 0.15
10 days	0.77 ± 0.16	0.73 ± 0.17	0.270 ± 0.156	0.266 ± 0.166	0.84 ± 0.072	0.75 ± 0.178
14 days	5.88 ± 2.12	6.49 ± 1.52	0.832 ± 0.41	1.172 ± 0.61	9.08 ± 0.70	12.04 ± 2.81
21 days	11.21 ± 3.38	19.48 ± 3.16 ^a	1.39 ± 0.64	4.03 ± 0.42 ^c	10.31 ± 3.61	28.87 ± 4.31 ^c	1.88 ± 1.58	2.58 ± 0.56
30 days	31.24 ± 6.76	42.32 ± 1.95 ^b	5.91 ± 1.79	12.28 ± 5.12 ^a	18.48 ± 4.21	29.78 ± 5.08^b	86.10 ± 19.51	103.42 ± 8.65
60 days	16.43 ± 8.61	26.94 ± 4.75 ^a	3.92 ± 1.85	11.35 ± 4.85 ^a	23.38 ± 8.38	28.08 ± 8.04	42.36 ± 12.64	50.01 ± 12.54
90 days	31.64 ± 9.54	16.44 ± 5.82 ^a	11.16 ± 1.95	7.34 ± 1.29 ^a	36.14 ± 11.0	20.69 ± 5.78 ^a	72.66 ± 13.00	47.49 ± 16.16 ^a
120 days	43.47 ± 9.30	35.64 ± 5.78	28.33 ± 6.51	23.08 ± 4.67	41.46 ± 9.94	29.72 ± 1.67	41.16 ± 5.75	29.84 ± 7.02^a
180 days	48.72 ± 10.71	34.30 ± 5.18	25.31 ± 8.59	15.95 ± 2.76	53.70 ± 9.37	43.01 ± 15.71	57.05 ± 12.14	37.70 ± 4.88 ^a
240 days	67.24 ± 13.04	43.44 ± 4.51 ^a	26.29 ± 4.34	12.03 ± 1.11 ^a	56.68 ± 8.59	36.16 ± 5.15 ^c	52.03 ± 11.06	32.08 ± 6.66 ^c
360 days	58.62 ± 40.10	26.10 ± 6.56	15.57 ± 3.99	7.61 ± 4.61 ^a	34.03 ± 13.0	17.70 ± 1.24^c	95.74 ± 27.93	58.76 ± 8.11^a

Unpaired 't' test was used; Values are Mean ± SD of 5 estimations; ^a p < 0.05; ^b p < 0.01; ^c p < 0.001 Statistical comparisons are between wild type control and TG mice at each individual age.

ISSN: 1477-7827