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Table 1 -

From: Differentiation of adult-type Leydig cells occurs in gonadotrophin-deficient mice

Gene Expression per testis (relative to Luciferase × 103) GnRH-null relative to adult normal (corrected for cell number)2
  Adult GnRH-null Adult normal Neonatal normal1  
P450scc 0.23 ± 0.04 242 ± 35 2.2 ± 0.5 0.95%
P450c17 15.3 ± 1.8 3453 ± 1042 13.5 ± 3.5 4.4%
GST5-5 60.6 ± 5.6 677 ± 91 76 ± 15 89.5%
RLF 19.2 ± 2.1 2490 ± 611 5.3 ± 1.3 7.7%
3βHSD I 7.5 ± 1.7 51 ± 10 4.6 ± 1.8 147.0%
Renin 0.027 ± 0.012 21.4 ± 3.5 5.8 ± 0.9 1.3%
EH 18.5 ± 1.6 996 ± 112 8.0 ± 1.6 18.5%
StAR 2.08 ± 0.2 177 ± 30 4.0 ± 1.1 11.7%
3βHSD VI* 0.014 ± 0.005 124 ± 15 ND3 0.11%
PGD-synthetase* 0.26 ± 0.06 843 ± 43 2.5 ± 1.1 0.31%
EST* 0.014 ± 0.009 9.0 ± 2.4 ND3 1.5%
17βHSD III* 2.39 ± 0.21 1644 ± 192 140 ± 7 1.45%
  1. * Genes expressed in adult Leydig cells but not fetal Leydig cells 1Neonatal animals were 5 days old. 2 Expression in GnRH-null mice is expressed as a percentage of normal mice and corrected for reduced Leydig cell number in GnRH-null animals [4]. 3ND = not detectable.