Abnormally ruptured follicle from the indomethacin-treated rat at 09:00 h in estrus. In A, the rupture site in the follicle can be observed. The route of granulosa cells and follicular fluid, invading the interstitial tissue and blood vessels, is indicated by arrows. The framed area, inside the blood vessel, is shown at higher magnification (insert), to show the presence of abundant neutrophils in the blood vessel lumen, surrounding granulosa cells and follicular fluid. In an adjacent section (B), the cumulus containing the oocyte in metaphase II can be observed. Clusters of neutrophils are indicated by open arrows. Scale bars in A = 120 μm; in B = 60 μm.