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Table 1 Association of pregnancy complications and thrombophilias

From: Thrombophilia and pregnancy

  Mild preeclampsia Severe preeclampsia IUGR Placental abruption
Antithrombin deficiency   ++ ++ +
Protein S deficiency   ++ ++ ++
Protein C deficiency   ++ ++  
APC resistance   ++ ++ ++
Factor V Leiden   ++   ++
MTHFR C677T     +
Hyperhomocysteinemia   ++ ++ ++
Factor II G 20210A   + ++ ++
Antiphospholipid syndrome   ++ ++ ++
Combined defects   ++ ++ ++
  1. Degree of association : + possible association; established association ++