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  1. Research

    Efficient vitrification of mouse embryos using the Kitasato Vitrification System as a novel vitrification device

    Currently, the cryopreservation of embryos and oocytes is essential for assisted reproductive technology (ART) laboratories worldwide. This study aimed to evaluate the efficacy of the Kitasato Vitrification Sy...

    Kenji Momozawa, Atsushi Matsuzawa, Yukio Tokunaga, Shiori Abe, Yumi Koyanagi, Miho Kurita, Marina Nakano and Takao Miyake

    Reproductive Biology and Endocrinology 2017 15:29

    Published on: 24 April 2017

  2. Research

    Immunolocalization of steroidogenic enzymes in the vaginal mucous of Galea spixii during the estrous cycle

    The synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthe...

    Amilton Cesar dos Santos, Alan James Conley, Moacir Franco de Oliveira, Gleidson Benevides Oliveira, Diego Carvalho Viana and Antônio Chaves de Assis Neto

    Reproductive Biology and Endocrinology 2017 15:30

    Published on: 24 April 2017

  3. Research

    Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model

    Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disorder caused by maternal antibodies against paternal human platelet antigens (HPAs) on fetal platelets. Antibodies against HPA-1a are acc...

    Mariana Eksteen, Gøril Heide, Heidi Tiller, Yan Zhou, Nora Hersoug Nedberg, Inigo Martinez-Zubiaurre, Anne Husebekk, Bjørn R. Skogen, Tor B. Stuge and Mette Kjær

    Reproductive Biology and Endocrinology 2017 15:28

    Published on: 21 April 2017

  4. Research

    Mitochondrial content, oxidative, and nitrosative stress in human full-term placentas with gestational diabetes mellitus

    The purpose of this study was to determine the mitochondrial content, and the oxidative and nitrosative stress of the placenta in women with gestational diabetes mellitus (GDM).

    Joel Ramírez-Emiliano, Martha E. Fajardo-Araujo, Ismael Zúñiga-Trujillo, Victoriano Pérez-Vázquez, Cuauhtémoc Sandoval-Salazar and Jessica K. Órnelas-Vázquez

    Reproductive Biology and Endocrinology 2017 15:26

    Published on: 4 April 2017

  5. Research

    Increased Krüppel-like factor 12 in recurrent implantation failure impairs endometrial decidualization by repressing Nur77 expression

    Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. A critical role of impaired decidualization in subfertility has been established. In human endometrial stromal ...

    Chenyang Huang, Yue Jiang, Jianjun Zhou, Qiang Yan, Ruiwei Jiang, Xi Cheng, Jun Xing, Lijun Ding, Jianxin Sun, Guijun Yan and Haixiang Sun

    Reproductive Biology and Endocrinology 2017 15:25

    Published on: 31 March 2017

  6. Research

    Differential gene expression profiling of endometrium during the mid-luteal phase of the estrous cycle between a repeat breeder (RB) and non-RB cows

    Repeat breeding directly affects reproductive efficiency in cattle due to an increase in services per conception and calving interval. This study aimed to investigate whether changes in endometrial gene expres...

    Ken-Go Hayashi, Misa Hosoe, Keiichiro Kizaki, Shiori Fujii, Hiroko Kanahara, Toru Takahashi and Ryosuke Sakumoto

    Reproductive Biology and Endocrinology 2017 15:20

    Published on: 23 March 2017

  7. Research

    Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis

    Steroidogenesis is a complex, multi-steps biological process in which, cholesterol precursor is converted to steroids in a tissue specific and tropic hormone dependent manner. Given that steroidogenesis is ach...

    Jiaxin Li, Qian Zhou, Zhuang Ma, Meina Wang, Wen-Jun Shen, Salman Azhar, Zhigang Guo and Zhigang Hu

    Reproductive Biology and Endocrinology 2017 15:19

    Published on: 16 March 2017

  8. Research

    Mesenchymal stem cell-derived angiogenin promotes primodial follicle survival and angiogenesis in transplanted human ovarian tissue

    We have recently reported that human bone marrow-derived mesenchymal stem cells (MSCs) facilitate angiogenesis and prevent follicle loss in xenografted human ovarian tissues. However, the mechanism underlying ...

    Yaoyao Zhang, Xi Xia, Jie Yan, Liying Yan, Cuilin Lu, Xiaohui Zhu, Tianren Wang, Tailang Yin, Rong Li, Hsun-Ming Chang and Jie Qiao

    Reproductive Biology and Endocrinology 2017 15:18

    Published on: 9 March 2017

  9. Research

    An open-label clinical trial to investigate the efficacy and safety of corifollitropin alfa combined with hCG in adult men with hypogonadotropic hypogonadism

    Hypogonadotropic hypogonadism (HH) in men results in insufficient testicular function and deficiencies in testosterone and spermatogenesis. Combinations of human chorionic gonadotropin (hCG) and recombinant fo...

    Eberhard Nieschlag, Pierre-Marc G. Bouloux, Barbara J. Stegmann, R. Ravi Shankar, Yanfen Guan, Anjela Tzontcheva, Christine McCrary Sisk and Hermann M. Behre

    Reproductive Biology and Endocrinology 2017 15:17

    Published on: 7 March 2017

  10. Research

    Chronic endometritis modifies decidualization in human endometrial stromal cells

    Chronic endometritis (CE) is a continuous inflammation of uterine endometrium, and it is usually symptomless. As CE has been thought not to affect the reproductive status and general health of affected women, ...

    Di Wu, Fuminori Kimura, Luyi Zheng, Mitsuaki Ishida, Yoko Niwa, Kimiko Hirata, Akie Takebayashi, Akiko Takashima, Kentaro Takahashi, Ryoji Kushima, Guangmei Zhang and Takashi Murakami

    Reproductive Biology and Endocrinology 2017 15:16

    Published on: 4 March 2017

  11. Research

    Expression of SOX2, NANOG and OCT4 in a mouse model of lipopolysaccharide-induced acute uterine injury and intrauterine adhesions

    Activation of inflammation-mediated endometrial injury is suggested to play a decisive role in pathogenesis of intrauterine adhesion (IUA). The stem cell theory of endometrial diseases has been given a hotspot...

    Li Xiao, Yong Song, Wei Huang, Shiyuan Yang, Jing Fu, Xue Feng and Min Zhou

    Reproductive Biology and Endocrinology 2017 15:14

    Published on: 3 March 2017

  12. Review

    Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review

    Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 9–18% of women in reproductive age that causes hyperandrogenism and infertility due to dysfunctional follicular maturation and anovula...

    Larissa Paixão, Ramon B. Ramos, Anita Lavarda, Debora M. Morsh and Poli Mara Spritzer

    Reproductive Biology and Endocrinology 2017 15:12

    Published on: 10 February 2017

  13. Research

    REAC technology as optimizer of stallion spermatozoa liquid storage

    REAC technology (acronym for Radio Electric Asymmetric Conveyor) is a technology platform for neuro and bio modulation. It has already proven to optimize the ions fluxes at the molecular level and the molecula...

    Fiammetta Berlinguer, Valeria Pasciu, Sara Succu, Ignazio Cossu, Sabrina Caggiu, Daniela Addis, Alessandro Castagna, Vania Fontani, Salvatore Rinaldi and Eraldo Sanna Passino

    Reproductive Biology and Endocrinology 2017 15:11

    Published on: 8 February 2017

  14. Research

    The Human Oocyte Preservation Experience (HOPE) Registry: evaluation of cryopreservation techniques and oocyte source on outcomes

    This prospective, Phase IV, multicenter, observational registry of assisted reproductive technology clinics in the USA studied outcomes of first cycles using thawed/warmed cryopreserved (by slow-freezing/vitri...

    Zsolt Peter Nagy, Robert E. Anderson, Eve C. Feinberg, Brooke Hayward and Mary C. Mahony

    Reproductive Biology and Endocrinology 2017 15:10

    Published on: 7 February 2017

  15. Research

    An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients

    Studies found that AGE-RAGE system is closely related to insulin resistance and hyperandrogenemia, which are two core pathophysiological processes in polycystic ovary syndrome (PCOS). This study is to investig...

    Yu Liao, Rong Huang, Yun Sun, Jiang Yue, Jun Zheng, Lihua Wang, Tao Tao, Jing Ma, Shengxian Li and Wei Liu

    Reproductive Biology and Endocrinology 2017 15:9

    Published on: 26 January 2017

  16. Research

    The impact of endometriosis on the outcome of Assisted Reproductive Technology

    Endometriosis has been described to impair fertility through various mechanisms. However, studies evaluating the reproductive outcomes of women undergoing assisted reproductive technologies show controversial ...

    Mireia González-Comadran, Juan Enrique Schwarze, Fernando Zegers-Hochschild, Maria do Carmo B. Souza, Ramon Carreras and Miguel Ángel Checa

    Reproductive Biology and Endocrinology 2017 15:8

    Published on: 24 January 2017

  17. Research

    Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy

    The lifesaving chemotherapy and radiation treatments that allow patients to survive cancer can also result in a lifetime of side-effects, including male infertility. Infertility in male cancer survivors is tho...

    Travis Kotzur, Roberto Benavides-Garcia, Jennifer Mecklenburg, Jamila R. Sanchez, Matthew Reilly and Brian P. Hermann

    Reproductive Biology and Endocrinology 2017 15:7

    Published on: 11 January 2017

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