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  1. Research

    Differential gene expression profiling of endometrium during the mid-luteal phase of the estrous cycle between a repeat breeder (RB) and non-RB cows

    Repeat breeding directly affects reproductive efficiency in cattle due to an increase in services per conception and calving interval. This study aimed to investigate whether changes in endometrial gene expres...

    Ken-Go Hayashi, Misa Hosoe, Keiichiro Kizaki, Shiori Fujii, Hiroko Kanahara, Toru Takahashi and Ryosuke Sakumoto

    Reproductive Biology and Endocrinology 2017 15:20

    Published on: 23 March 2017

  2. Research

    Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis

    Steroidogenesis is a complex, multi-steps biological process in which, cholesterol precursor is converted to steroids in a tissue specific and tropic hormone dependent manner. Given that steroidogenesis is ach...

    Jiaxin Li, Qian Zhou, Zhuang Ma, Meina Wang, Wen-Jun Shen, Salman Azhar, Zhigang Guo and Zhigang Hu

    Reproductive Biology and Endocrinology 2017 15:19

    Published on: 16 March 2017

  3. Research

    Mesenchymal stem cell-derived angiogenin promotes primodial follicle survival and angiogenesis in transplanted human ovarian tissue

    We have recently reported that human bone marrow-derived mesenchymal stem cells (MSCs) facilitate angiogenesis and prevent follicle loss in xenografted human ovarian tissues. However, the mechanism underlying ...

    Yaoyao Zhang, Xi Xia, Jie Yan, Liying Yan, Cuilin Lu, Xiaohui Zhu, Tianren Wang, Tailang Yin, Rong Li, Hsun-Ming Chang and Jie Qiao

    Reproductive Biology and Endocrinology 2017 15:18

    Published on: 9 March 2017

  4. Research

    An open-label clinical trial to investigate the efficacy and safety of corifollitropin alfa combined with hCG in adult men with hypogonadotropic hypogonadism

    Hypogonadotropic hypogonadism (HH) in men results in insufficient testicular function and deficiencies in testosterone and spermatogenesis. Combinations of human chorionic gonadotropin (hCG) and recombinant fo...

    Eberhard Nieschlag, Pierre-Marc G. Bouloux, Barbara J. Stegmann, R. Ravi Shankar, Yanfen Guan, Anjela Tzontcheva, Christine McCrary Sisk and Hermann M. Behre

    Reproductive Biology and Endocrinology 2017 15:17

    Published on: 7 March 2017

  5. Research

    Chronic endometritis modifies decidualization in human endometrial stromal cells

    Chronic endometritis (CE) is a continuous inflammation of uterine endometrium, and it is usually symptomless. As CE has been thought not to affect the reproductive status and general health of affected women, ...

    Di Wu, Fuminori Kimura, Luyi Zheng, Mitsuaki Ishida, Yoko Niwa, Kimiko Hirata, Akie Takebayashi, Akiko Takashima, Kentaro Takahashi, Ryoji Kushima, Guangmei Zhang and Takashi Murakami

    Reproductive Biology and Endocrinology 2017 15:16

    Published on: 4 March 2017

  6. Research

    Expression of SOX2, NANOG and OCT4 in a mouse model of lipopolysaccharide-induced acute uterine injury and intrauterine adhesions

    Activation of inflammation-mediated endometrial injury is suggested to play a decisive role in pathogenesis of intrauterine adhesion (IUA). The stem cell theory of endometrial diseases has been given a hotspot...

    Li Xiao, Yong Song, Wei Huang, Shiyuan Yang, Jing Fu, Xue Feng and Min Zhou

    Reproductive Biology and Endocrinology 2017 15:14

    Published on: 3 March 2017

  7. Review

    Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review

    Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 9–18% of women in reproductive age that causes hyperandrogenism and infertility due to dysfunctional follicular maturation and anovula...

    Larissa Paixão, Ramon B. Ramos, Anita Lavarda, Debora M. Morsh and Poli Mara Spritzer

    Reproductive Biology and Endocrinology 2017 15:12

    Published on: 10 February 2017

  8. Research

    REAC technology as optimizer of stallion spermatozoa liquid storage

    REAC technology (acronym for Radio Electric Asymmetric Conveyor) is a technology platform for neuro and bio modulation. It has already proven to optimize the ions fluxes at the molecular level and the molecula...

    Fiammetta Berlinguer, Valeria Pasciu, Sara Succu, Ignazio Cossu, Sabrina Caggiu, Daniela Addis, Alessandro Castagna, Vania Fontani, Salvatore Rinaldi and Eraldo Sanna Passino

    Reproductive Biology and Endocrinology 2017 15:11

    Published on: 8 February 2017

  9. Research

    The Human Oocyte Preservation Experience (HOPE) Registry: evaluation of cryopreservation techniques and oocyte source on outcomes

    This prospective, Phase IV, multicenter, observational registry of assisted reproductive technology clinics in the USA studied outcomes of first cycles using thawed/warmed cryopreserved (by slow-freezing/vitri...

    Zsolt Peter Nagy, Robert E. Anderson, Eve C. Feinberg, Brooke Hayward and Mary C. Mahony

    Reproductive Biology and Endocrinology 2017 15:10

    Published on: 7 February 2017

  10. Research

    An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients

    Studies found that AGE-RAGE system is closely related to insulin resistance and hyperandrogenemia, which are two core pathophysiological processes in polycystic ovary syndrome (PCOS). This study is to investig...

    Yu Liao, Rong Huang, Yun Sun, Jiang Yue, Jun Zheng, Lihua Wang, Tao Tao, Jing Ma, Shengxian Li and Wei Liu

    Reproductive Biology and Endocrinology 2017 15:9

    Published on: 26 January 2017

  11. Research

    The impact of endometriosis on the outcome of Assisted Reproductive Technology

    Endometriosis has been described to impair fertility through various mechanisms. However, studies evaluating the reproductive outcomes of women undergoing assisted reproductive technologies show controversial ...

    Mireia González-Comadran, Juan Enrique Schwarze, Fernando Zegers-Hochschild, Maria do Carmo B. Souza, Ramon Carreras and Miguel Ángel Checa

    Reproductive Biology and Endocrinology 2017 15:8

    Published on: 24 January 2017

  12. Research

    Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy

    The lifesaving chemotherapy and radiation treatments that allow patients to survive cancer can also result in a lifetime of side-effects, including male infertility. Infertility in male cancer survivors is tho...

    Travis Kotzur, Roberto Benavides-Garcia, Jennifer Mecklenburg, Jamila R. Sanchez, Matthew Reilly and Brian P. Hermann

    Reproductive Biology and Endocrinology 2017 15:7

    Published on: 11 January 2017

  13. Research

    Human LH and hCG stimulate differently the early signalling pathways but result in equal testosterone synthesis in mouse Leydig cells in vitro

    Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) are glycoprotein hormones regulating development and reproductive functions by acting on the same receptor (LHCGR). We compared the LH and hCG ac...

    Laura Riccetti, Francesco De Pascali, Lisa Gilioli, Francesco Potì, Lavinia Beatrice Giva, Marco Marino, Simonetta Tagliavini, Tommaso Trenti, Flaminia Fanelli, Marco Mezzullo, Uberto Pagotto, Manuela Simoni and Livio Casarini

    Reproductive Biology and Endocrinology 2017 15:2

    Published on: 5 January 2017

  14. Research

    Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters

    There are reports showing that l-carnitine alone or in combination with other micronutrients improve sperm parameters. However, comparative studies are still lacking. This study was carried out to compare the ...

    Markus Lipovac, Florian Bodner, Martin Imhof and Peter Chedraui

    Reproductive Biology and Endocrinology 2016 14:84

    Published on: 9 December 2016

  15. Research

    Arrest at the diplotene stage of meiotic prophase I is delayed by progesterone but is not required for primordial follicle formation in mice

    In mammalian females, reproductive capacity is determined by the size of the primordial follicle pool. During embryogenesis, oogonia divide mitotically but cytokinesis is incomplete so oogonia remain connected...

    Sudipta Dutta, Deion M. Burks and Melissa E. Pepling

    Reproductive Biology and Endocrinology 2016 14:82

    Published on: 5 December 2016

  16. Research

    Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients

    Current evidence suggests that endometrial-derived stem cells, spilled in the peritoneal cavity via retrograde menstruation, are key players in the establishment of endometriotic lesions. The aim of this study...

    Katharina Proestling, Peter Birner, Sukirthini Balendran, Nadine Nirtl, Erika Marton, Gülen Yerlikaya, Lorenz Kuessel, Theresa Reischer, Rene Wenzl, Berthold Streubel and Heinrich Husslein

    Reproductive Biology and Endocrinology 2016 14:81

    Published on: 24 November 2016

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