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  1. Research

    p,p’-DDT induces testicular oxidative stress-induced apoptosis in adult rats

    The 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p’-DDT) is a known persistent organic pollutant and male reproductive toxicant. The present study is designed to test the hypothesis that oxidative stress m...

    Neila Marouani, Dorsaf Hallegue, Mohsen Sakly, Moncef Benkhalifa, Khémais Ben Rhouma and Olfa Tebourbi

    Reproductive Biology and Endocrinology 2017 15:40

    Published on: 26 May 2017

  2. Research

    Outcome of in vitro fertilization in women with subclinical hypothyroidism

    Previous studies examining associations between subclinical hypothyroidism (SCH) with in vitro fertilization (IVF) outcome indicate some benefits of levothyroxine (LT4) treatment. But IVF outcomes in treated S...

    YunYing Cai, LanPing Zhong, Jie Guan, RuiJin Guo, Ben Niu, YanPing Ma and Heng Su

    Reproductive Biology and Endocrinology 2017 15:39

    Published on: 25 May 2017

  3. Review

    Role of microRNAs in premature ovarian insufficiency

    Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follic...

    Ying Guo, Junyan Sun and Dongmei Lai

    Reproductive Biology and Endocrinology 2017 15:38

    Published on: 12 May 2017

  4. Research

    Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator

    The aim of this study was to compare pregnancy rates in patients undergoing IVF/ICSI with embryo transfer after 4 and 5 days of culture in a closed incubation system with integrated time-lapse imaging.

    Verena Holschbach, Julia Weigert, Jens Erik Dietrich, Sabine Roesner, Markus Montag, Thomas Strowitzki and Bettina Toth

    Reproductive Biology and Endocrinology 2017 15:37

    Published on: 8 May 2017

  5. Review

    Comparative neonatal outcomes in singleton births from blastocyst transfers or cleavage-stage embryo transfers: a systematic review and meta-analysis

    Comparative neonatal outcomes with respect to singleton births from blastocyst transfers or cleavage-state embryo transfers are controversial with respect to which method is superior. Many studies have yielded...

    Xingling Wang, Mingze Du, Yichun Guan, Bijun Wang, Junwei Zhang and Zihua Liu

    Reproductive Biology and Endocrinology 2017 15:36

    Published on: 4 May 2017

  6. Research

    Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats

    Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory ho...

    Xinghui Han, Yuanyuan He, Gulan Zeng, Yonghong Wang, Wen Sun, Junchao Liu, Yanyan Sun and Jian Yu

    Reproductive Biology and Endocrinology 2017 15:35

    Published on: 2 May 2017

  7. Research

    Association of skewed X-chromosome inactivation with FMR1 CGG repeat length and anti-Mullerian hormone levels: a cohort study

    Premutation range CGGn repeats of the FMR1 gene denote risk toward primary ovarian insufficiency (POI), also called premature ovarian failure (POF). This prospective cohort study was undertaken to determine if...

    David H. Barad, Sarah Darmon, Andrea Weghofer, Gary J. Latham, Filipovic-Sadic, Qi Wang, Vitaly A. Kushnir, David F. Albertini and Norbert Gleicher

    Reproductive Biology and Endocrinology 2017 15:34

    Published on: 28 April 2017

  8. Research

    A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use

    It has become increasingly apparent that the trophectoderm (TE) at blastocyst stage is much more mosaic than has been appreciated. Whether preimplantation genetic screening (PGS), utilizing a single TE biopsy ...

    Norbert Gleicher, Jacob Metzger, Gist Croft, Vitaly A. Kushnir, David F. Albertini and David H Barad

    Reproductive Biology and Endocrinology 2017 15:33

    Published on: 27 April 2017

  9. Research

    Effect of different artificial shrinkage methods, when applied before blastocyst vitrification, on perinatal outcomes

    In recent years, single blastocyst transfer combined with vitrification has been applied widely, which can maximize the cumulative pregnancy rate in per oocyte retrieval cycles and minimize the multiple pregna...

    Caizhu Wang, Guixue Feng, Bo Zhang, Hong Zhou, Jinhui Shu, Ruoyun Lin, Huanhua Chen and Zhulian Wu

    Reproductive Biology and Endocrinology 2017 15:32

    Published on: 26 April 2017

  10. Research

    Improving preimplantation genetic diagnosis (PGD) reliability by selection of sperm donor with the most informative haplotype

    The study is aimed to describe a novel strategy that increases the accuracy and reliability of PGD in patients using sperm donation by pre-selecting the donor whose haplotype does not overlap the carrier’s one.

    Mira Malcov, Veronica Gold, Sagit Peleg, Tsvia Frumkin, Foad Azem, Ami Amit, Dalit Ben-Yosef, Yuval Yaron, Adi Reches, Shimi Barda, Sandra E. Kleiman, Leah Yogev and Ron Hauser

    Reproductive Biology and Endocrinology 2017 15:31

    Published on: 26 April 2017

  11. Research

    Efficient vitrification of mouse embryos using the Kitasato Vitrification System as a novel vitrification device

    Currently, the cryopreservation of embryos and oocytes is essential for assisted reproductive technology (ART) laboratories worldwide. This study aimed to evaluate the efficacy of the Kitasato Vitrification Sy...

    Kenji Momozawa, Atsushi Matsuzawa, Yukio Tokunaga, Shiori Abe, Yumi Koyanagi, Miho Kurita, Marina Nakano and Takao Miyake

    Reproductive Biology and Endocrinology 2017 15:29

    Published on: 24 April 2017

  12. Research

    Immunolocalization of steroidogenic enzymes in the vaginal mucous of Galea spixii during the estrous cycle

    The synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthe...

    Amilton Cesar dos Santos, Alan James Conley, Moacir Franco de Oliveira, Gleidson Benevides Oliveira, Diego Carvalho Viana and Antônio Chaves de Assis Neto

    Reproductive Biology and Endocrinology 2017 15:30

    Published on: 24 April 2017

  13. Research

    Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model

    Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disorder caused by maternal antibodies against paternal human platelet antigens (HPAs) on fetal platelets. Antibodies against HPA-1a are acc...

    Mariana Eksteen, Gøril Heide, Heidi Tiller, Yan Zhou, Nora Hersoug Nedberg, Inigo Martinez-Zubiaurre, Anne Husebekk, Bjørn R. Skogen, Tor B. Stuge and Mette Kjær

    Reproductive Biology and Endocrinology 2017 15:28

    Published on: 21 April 2017

  14. Research

    Mitochondrial content, oxidative, and nitrosative stress in human full-term placentas with gestational diabetes mellitus

    The purpose of this study was to determine the mitochondrial content, and the oxidative and nitrosative stress of the placenta in women with gestational diabetes mellitus (GDM).

    Joel Ramírez-Emiliano, Martha E. Fajardo-Araujo, Ismael Zúñiga-Trujillo, Victoriano Pérez-Vázquez, Cuauhtémoc Sandoval-Salazar and Jessica K. Órnelas-Vázquez

    Reproductive Biology and Endocrinology 2017 15:26

    Published on: 4 April 2017

  15. Research

    Increased Krüppel-like factor 12 in recurrent implantation failure impairs endometrial decidualization by repressing Nur77 expression

    Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. A critical role of impaired decidualization in subfertility has been established. In human endometrial stromal ...

    Chenyang Huang, Yue Jiang, Jianjun Zhou, Qiang Yan, Ruiwei Jiang, Xi Cheng, Jun Xing, Lijun Ding, Jianxin Sun, Guijun Yan and Haixiang Sun

    Reproductive Biology and Endocrinology 2017 15:25

    Published on: 31 March 2017

  16. Research

    Differential gene expression profiling of endometrium during the mid-luteal phase of the estrous cycle between a repeat breeder (RB) and non-RB cows

    Repeat breeding directly affects reproductive efficiency in cattle due to an increase in services per conception and calving interval. This study aimed to investigate whether changes in endometrial gene expres...

    Ken-Go Hayashi, Misa Hosoe, Keiichiro Kizaki, Shiori Fujii, Hiroko Kanahara, Toru Takahashi and Ryosuke Sakumoto

    Reproductive Biology and Endocrinology 2017 15:20

    Published on: 23 March 2017

  17. Research

    Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis

    Steroidogenesis is a complex, multi-steps biological process in which, cholesterol precursor is converted to steroids in a tissue specific and tropic hormone dependent manner. Given that steroidogenesis is ach...

    Jiaxin Li, Qian Zhou, Zhuang Ma, Meina Wang, Wen-Jun Shen, Salman Azhar, Zhigang Guo and Zhigang Hu

    Reproductive Biology and Endocrinology 2017 15:19

    Published on: 16 March 2017

  18. Research

    Mesenchymal stem cell-derived angiogenin promotes primodial follicle survival and angiogenesis in transplanted human ovarian tissue

    We have recently reported that human bone marrow-derived mesenchymal stem cells (MSCs) facilitate angiogenesis and prevent follicle loss in xenografted human ovarian tissues. However, the mechanism underlying ...

    Yaoyao Zhang, Xi Xia, Jie Yan, Liying Yan, Cuilin Lu, Xiaohui Zhu, Tianren Wang, Tailang Yin, Rong Li, Hsun-Ming Chang and Jie Qiao

    Reproductive Biology and Endocrinology 2017 15:18

    Published on: 9 March 2017

  19. Research

    An open-label clinical trial to investigate the efficacy and safety of corifollitropin alfa combined with hCG in adult men with hypogonadotropic hypogonadism

    Hypogonadotropic hypogonadism (HH) in men results in insufficient testicular function and deficiencies in testosterone and spermatogenesis. Combinations of human chorionic gonadotropin (hCG) and recombinant fo...

    Eberhard Nieschlag, Pierre-Marc G. Bouloux, Barbara J. Stegmann, R. Ravi Shankar, Yanfen Guan, Anjela Tzontcheva, Christine McCrary Sisk and Hermann M. Behre

    Reproductive Biology and Endocrinology 2017 15:17

    Published on: 7 March 2017

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